Keep out of the sight and reach of children. Simparica does not require any special storage conditions.Īny unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements. In case of accidental ingestion, seek medical advice immediately and show the package leaflet or label to the physician. The blister pack should then be returned into the carton immediately after use and the carton should be stored out of the sight and reach of children.
To prevent children from accessing the product, only one chewable tablet at a time should be removed from the blister pack and only when required. The accidental ingestion of the product may potentially result in adverse effects, such as transient excitatory neurological signs. No treatment-related clinical signs were observed. Sarolaner is well tolerated in Collies with a deficient multidrug-resistance-protein 1 (MDR1 -/-) following single oral administration at 5 times the recommended dose. In the overdose groups, transient and self-limiting neurological signs were observed in some animals: mild tremors at 3 times the maximum dose and convulsions at 5 times the maximum dose. No adverse effects were observed at the maximum dose of 4 mg/kg. Simparica has been administered orally to 8 week old Beagle puppies at doses of 0, 1, 3, and 5 times the maximum dose of 4 mg/kg at 28 day intervals for 10 doses. Use only according to the benefit/risk assessment by the responsible veterinarian. Laboratory studies in rats and rabbits have not produced any evidence of any teratogenic effects. The safety of Simparica has not been established during pregnancy and lactation or in animals intended for breeding. These signs typically resolve without treatment. In very rare cases transient neurological disorders such as tremor, ataxia or convulsion may occur. In very rare cases (less than 1 animal in 10,000 animals treated, including isolated reports) adverse reactions associated with mild and transient gastrointestinal effects such as vomiting and diarrhoea may occur. In the absence of available data, treatment of puppies less than 8 weeks of age and/or dogs less than 1.3 kg bodyweight should be based on a benefit-risk assessment by the responsible veterinarian. Parasites need to start feeding on the host to become exposed to sarolaner therefore, the transmission of infectious parasite-borne diseases cannot be excluded. This entry was posted in Article on Augby locustvalleyvet.Do not use in cases of hypersensitivity to the active substance or to any of the excipients. Be wary of the online and mail order houses. Stick with name brands and known retailers. What is also important is where you get your prescriptions filled, and where you buy your over the counter drugs. It is best to seek out advise from your physician or veterinarian. But, other drugs like aspirin and other NSAIDS do not lose their potency for years after the listed expiration dates. There is no question that expiration dates should be adhered to with certain critical drugs like insulin, nitroglycerin, phenobarbital, statins, liquid antibiotics, etc.
“Manufacturers put expiration dates on for marketing purposes, rather than scientific reasons.” The dates are based on economics.
“Do not use” after such and such date is just an advertising ploy. In fact, many drugs were found to have the same potency for up to ten years after the expiration date. Although some drugs may lose some of their potency over time, maybe as little as 5%, many are good for years after the expiration date. Second, the medical authorities state that it is safe to take most drugs after the expiration date. It does not mean how long the drug is actually good for, or safe to use.
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But, the date only means that the manufacturer guarantees the full potency and safety of the drug up to that date. Here are some of the facts from the medical authorities after several studies were performed: First, the expiration date is required by law, at least in the United States. What actually happens if the drug is used after the expiration date? Can it cause harm, does it help, does the potency change? Does the date really mean at that moment stop using it? Does it gradually spoil? A study was performed and the results were a surprise to many and shocking to others. The terms “use before” the following date are stamped on most pharmaceuticals for human and animal use.
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